Status:
COMPLETED
Per Oral Versus Intravenous Postoperative Antibiotics After Surgery for Complicated Appendicitis.
Lead Sponsor:
Zealand University Hospital
Conditions:
Complicated Appendicitis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The PIPA trial is a prospective, multicentre, cluster randomized cluster crossover non-inferiority study. We aim to test whether a three-day postoperative course of per oral antibiotics is non-inferio...
Detailed Description
Complicated appendicitis increases the risk of postoperative intra-abdominal abscess. Treatment of complicated appendicitis are usually with a postoperative course of intravenous antibiotics. There is...
Eligibility Criteria
Inclusion
- On cluster level, hospitals with emergency surgical admissions performing laparoscopic appendectomies are eligible for inclusion.
- On an individual level, participants are eligible for inclusion if they undergo a laparoscopic appendectomy for appendicitis (both uncomplicated and complicated), are ≥ 18 years of age, and provide a signed written consent form.
Exclusion
- Exclusion criteria are specifically related to the therapy and individual participants will be excluded if they undergo any other procedures than laparoscopic appendectomy during index surgery.
Key Trial Info
Start Date :
April 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2024
Estimated Enrollment :
3193 Patients enrolled
Trial Details
Trial ID
NCT04803422
Start Date
April 1 2021
End Date
June 30 2024
Last Update
October 1 2024
Active Locations (2)
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1
Slagelse Hospital, Department of Surgery
Slagelse, Denmark, 4200
2
Department of Surgery, Slagelse Hospital
Slagelse, Denmark