Status:
UNKNOWN
Role of Pseudomonas Aeruginosa Biofilms in Exacerbations in Patients With Bronchiectasis With and Without Chronic Obstructive Pulmonary Disease
Lead Sponsor:
Hospital Clinic of Barcelona
Collaborating Sponsors:
ISCIII
Conditions:
Bronchiectasis
Microbial Colonization
Eligibility:
All Genders
18+ years
Brief Summary
Exacerbations, in particular during chronic Pseudomonas aeruginosa (PA) infection, are very important in the prognosis of patients with non-cystic fibrosis bronchiectasis (BE). In Cystic Fibrosis pati...
Detailed Description
This project will study the association between chronic PA infection in the airways and the formation of biofilms in the following patient populations: 1-bronchiectasis not associated with cystic fibr...
Eligibility Criteria
Inclusion
- BE criteria (with and without COPD)
- Isolation of PA in sputum in the stable phase. \* A prospective screening of BQ patients in outpatient consultations will be conducted to prospectively detect those with isolation of PA in the sputum.
Exclusion
- CF
- Immunosuppression (primary and secondary, with the exception of cases of IgG deficiency in stable substitution treatment)
- Sarcoidosis
- Tuberculosis, active infection by nontuberculous mycobacteria
- Diffuse interstitial lung disease
- Altered state of consciousness or disability to understand the study and perform the tests provided by it, involving the patient in another intervention study (clinical trials).
- Patients with CF are excluded because the role of PA biofilms in CF has been extensively studied, as argued in the background of the present proposal and the selected literature. It is also a totally different disease from the one we intend to study, with patients of much younger ages. Finally, this is a very vulnerable population in which it would be very difficult to obtain all the samples sequentially.
Key Trial Info
Start Date :
March 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2021
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT04803695
Start Date
March 1 2018
End Date
December 1 2021
Last Update
March 18 2021
Active Locations (1)
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1
Hospital Clinic de Barcelona
Barcelona, Spain, 08036