Status:
ACTIVE_NOT_RECRUITING
Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) Trial
Lead Sponsor:
NHS National Waiting Times Centre Board
Collaborating Sponsors:
University of Glasgow
British Heart Foundation
Conditions:
Microvascular Angina
Angina Pectoris
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Anginal symptoms due to ischaemia with no obstructive coronary arteries (INOCA) is a common clinical problem, however, diagnosis and onward management is heterogeneous, and prognosis is affected. Rece...
Detailed Description
Background: There are approximately 2 million men and women living with angina in the UK. In 2014, there were \~247,000 coronary angiograms performed, mostly for the investigation of known or suspect...
Eligibility Criteria
Inclusion
- Age ≥18 years
- Symptoms of angina or angina-equivalent informed by the Rose Angina questionnaire.
- Coronary angiography ≤3 months with a plan for medical management.
Exclusion
- Obstructive coronary artery disease i.e. a stenosis \>70% in a single segment or 50 - 70% in 2 adjacent segments in an artery \>2.5 mm, or FFR ≤0.80.
- Coronary revascularization by percutaneous coronary intervention or coronary artery bypass graft surgery following the index angiogram.
- Prior coronary artery bypass surgery
- A diagnosis that would explain the angina e.g. anaemia, aortic stenosis, hypertrophic cardiomyopathy,
- Contra-indication to contrast-enhanced CMR e.g. eGFR \< 30mL/min/1.73m2.
- Contra-indication to intravenous adenosine, i.e. severe asthma; long QT syndrome; second- or third-degree AV block and sick sinus syndrome.
- Lack of informed consent.
Key Trial Info
Start Date :
February 9 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2034
Estimated Enrollment :
280 Patients enrolled
Trial Details
Trial ID
NCT04805814
Start Date
February 9 2021
End Date
October 1 2034
Last Update
January 30 2025
Active Locations (3)
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1
University Hospital Hairmyres
East Kilbride, Glasgow, United Kingdom, G75 8RG
2
University Hospital Ayr
Ayr, Scotland, United Kingdom, KA6 6D
3
Golden Jubilee National Hospital
Glasgow, Scotland, United Kingdom, G81 4DY