Status:
UNKNOWN
Retinal Neurodegeneration In Type 2 Diabetes Mellitus Detected by Optical Coherence Tomography
Lead Sponsor:
Assiut University
Conditions:
Retinal Neuropathy
Neurodegeneration
Eligibility:
All Genders
18-75 years
Brief Summary
Evaluation of retinal neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy or with mild non proliferative diabetic retinopathy
Detailed Description
Retinal complications in diabetes mellitus (DM) patients were typically considered part of a vascular process. However, recent studies suggest that ocular degeneration in DM might be caused by 2 diffe...
Eligibility Criteria
Inclusion
- All patients with confirmed type 2 DM diagnosis of at least 6 months
- Best-corrected visual acuity (BCVA) of 6/12 or higher (using a Snellen chart) in each eye
- Intraocular pressure (by applanation) less than 21 mmHg.
- Healthy controls had no record nor evidence of ocular or neurologic disease of any kind; their BCVA is \> 6/9 based on the Snellen scale.
Exclusion
- presence or past history of moderate or severe non proliferative diabetic retinopathy or proliferative diabetic retinopathy , confirmed by indirect funduscopy or retinography images.
- presence of significant refractive errors (≥5 diopters of spherical equivalent refraction or 3 diopters of astigmatism)
- intraocular pressure ≥21 mmHg
- media opacifications
- concomitant ocular diseases, including history of glaucoma or retinal pathology
- systemic conditions that could affect the visual system, including neurodegenerative disorders such as Parkinson's disease, multiple sclerosis, or dementia.
Key Trial Info
Start Date :
June 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2022
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04808804
Start Date
June 1 2021
End Date
June 1 2022
Last Update
March 23 2021
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