Status:
UNKNOWN
Non-invasive Photoacoustic Imaging of Skin Inflammatory Disorders With Machine Learning-assisted Scoring
Lead Sponsor:
Institute of Bioengineering and Bioimaging (IBB)
Collaborating Sponsors:
National Skin Centre, Singapore
Conditions:
Eczema
Psoriasis
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
Inflammatory skin disorders are usually assessed by disease scoring system such as Scoring AD (SCORAD)/Eczema Area and Severity Index (EASI) and Psoriasis Area and Severity Index (PASI) for atopic ecz...
Detailed Description
Inflammatory skin diseases are increasingly common in various industrialized western societies. In 2015, eczema or dermatitis, the most common inflammatory skin disease, is estimated to have affected ...
Eligibility Criteria
Inclusion
- Patients with a clinical diagnosis of atopic dermatitis based on either the United Kingdom Working Party criteria or the Hanifin and Rajka criteria, age 21 years and above, with or without diabetes mellitus
- Patients with diagnosis of active chronic plaque psoriasis clinically by managing dermatologist based on typical clinical features of psoriasis, with or without diabetes mellitus
- Healthy controls of age 21 years and above with no known chronic skin conditions, with or without diabetes mellitus
- Willingness to participate in the study and undergo skin physiological assessments, photoacoustic mesoscopic imaging, and confocal Raman spectroscopy
Exclusion
- Mentally incompetent, younger than 21 years of age, prisoners, pregnant or breastfeeding women
- Patients unable to provide informed consent
- Any medical condition which makes the candidate an inappropriate subject for study participation, in the investigator's judgment
Key Trial Info
Start Date :
February 22 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 31 2024
Estimated Enrollment :
550 Patients enrolled
Trial Details
Trial ID
NCT04809571
Start Date
February 22 2021
End Date
January 31 2024
Last Update
September 28 2022
Active Locations (1)
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1
National Skin Centre
Singapore, Singapore