Status:
NOT_YET_RECRUITING
MR-Linac for Head and Neck SBRT
Lead Sponsor:
Sunnybrook Health Sciences Centre
Conditions:
Head and Neck Cancer
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study will evaluate the feasibility and safety of using MR-guided adaptive Head and Neck stereotactic radiotherapy (SBRT) at each fraction on the 1.5T MR-Linac.
Detailed Description
At the Sunnybrook Odette Cancer Centre (OCC), stereotactic body radiation therapy (SBRT) (35- 50 Gy in 5 fractions delivered 2x/week) has been employed in a subgroup of palliative Head and Neck cancer...
Eligibility Criteria
Inclusion
- Patients aged 18 years and older
- Karnofsky performance status score of ≥70
- Biopsy-proven oligometastatic cancer to the HN
- Biopsy-proven primary HN cancer (either mucosal, nodal, skin)
- Patients deemed unsuitable by the treating radiation oncologist for radiation treatment with curative intent owing to advanced age, significant comorbidities, poor performance status, distant metastatic disease.
- ≥ 1 site amenable to HN SBRT
- Capable of providing informed consent
- Required to complete any systemic therapy ≥ 10 days prior to planned start of HN SBRT, with no plans to initiate systemic therapy ≥10 days following completion of HN SBRT.
Exclusion
- History of radiation within the projected treatment field
- Contraindications to MR imaging per institutional policy
- Patients with connective tissue disorders
- History of severe claustrophobia
- Pregnant and or breastfeeding females
- Having an estimated glomerular filtration rate (GFR) \<40 ml/min/1.73m2
Key Trial Info
Start Date :
June 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2030
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04809792
Start Date
June 1 2023
End Date
June 1 2030
Last Update
May 23 2023
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