Status:
RECRUITING
Surgical Resection of Latent Brain Tumors Prior to Recurrence
Lead Sponsor:
Mayo Clinic
Conditions:
Brain Neoplasm
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This clinical trial evaluates the side effects and possible benefits of operating on brain tumors prior to the tumor coming back (recurrence). Understanding when surgery is most useful to patients wit...
Detailed Description
PRIMARY OBJECTIVE: I. To evaluate the safety and feasibility of surgical resection for pre-recurrent brain tumors. SECONDARY OBJECTIVES: I. To determine whether there are differences in overall sur...
Eligibility Criteria
Inclusion
- Age \>= 18 years
- Histological or cytological confirmation of brain tumor and/or suspected brain tumor based on clinical and radiologic findings
- Prior chemotherapy and/or radiation treatment directed to the known/suspected tumor
- Radiographic evidence of residual or previously unresected tumor
- Willingness to undergo surgery and sign informed consent
- Patients not currently eligible for an alternate competing interventional clinical trial
- Enrollment in the Mayo Clinic Cancer Center Neuro-Oncology Program Registry for the study of Nervous System Tumors (IRB#12-003458)
Exclusion
- Age \< 18 years
- Found to be a member of a vulnerable population (e.g. pregnant, lacking capacity to consent) during the course of pre-enrollment or pre-surgical assessment
- Prior gross total resection of brain tumor leading to absence of visible latent disease (exemption available for post-operative enrollment)
- Any contraindication to surgery, including anyone who in the opinion of the surgeon is at unreasonably elevated risk of wound complications
- Patients who have not yet undergone surgery or radiation, but who would be appropriate candidates for an alternate interventional clinical trial (e.g. post-operative fractionated vs single fraction radiation to the surgical cavity for surgical brain metastases)
Key Trial Info
Start Date :
May 6 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2028
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04810871
Start Date
May 6 2021
End Date
March 1 2028
Last Update
May 21 2025
Active Locations (1)
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1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905