Status:
UNKNOWN
The Effect of Immunological Heterogeneity of Tumor Microenvironment in the Prognosis of Gastric Cancer
Lead Sponsor:
Fujian Medical University
Conditions:
Stomach Cancer
Eligibility:
All Genders
18-80 years
Brief Summary
The purpose of this study is to explore the effect of immunological heterogeneity of tumor microenvironment in the short-term outcome and long-term outcome of patients with gastric cancer.
Detailed Description
A prospective cohort study will be performed to explore the effect of immunological heterogeneity of tumor microenvironment in the short-term outcome and long-term outcome of patients with gastric can...
Eligibility Criteria
Inclusion
- Age from 18 to 80 years
- Histology confirmed gastric adenocarcinoma (papillary, tubular, mucinous, signet ring cell, or poorly differentiated) confirmed pathologically by endoscopic biopsy.
- Clinical stage: cTNM: stage I or above at preoperative evaluation according to the American Joint Committee on Cancer (AJCC) Cancer Staging Manual Eighth Edition
- Performance status: Eastern Cooperative Oncology Group (ECOG) ≤ 2 (normal to symptomatic but in bed less than half the day)
- Clinically fit for gastric cancer surgery, i.e. adequate renal, hepatic, hematologic, and pulmonary function.
- Written informed consent
Exclusion
- Women during pregnancy or breast-feeding
- Severe mental disorder
- History of previous gastrectomy, endoscopic mucosal resection, or endoscopic submucosal dissection
- History of other malignant diseases within the past five years
- History of unstable angina or myocardial infarction within the past six months
- History of a cerebrovascular accident within the past six months
- History of continuous systematic administration of corticosteroids within one month
- Requirement of simultaneous surgery for other diseases
- Emergency surgery due to complication (bleeding, obstruction, or perforation) caused by gastric cancer
- Forced expiratory volume in 1 second (FEV1)\<50% of predicted values
- Inclusion in another clinical trial
Key Trial Info
Start Date :
March 31 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 30 2021
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04819958
Start Date
March 31 2021
End Date
August 30 2021
Last Update
April 15 2021
Active Locations (1)
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1
Department of Gastric Surgery
Fuzhou, Fujian, China