Status:
COMPLETED
Topical Insulin - Utility and Results in Neurotrophic Keratopathy in Stages 2 and 3
Lead Sponsor:
Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Conditions:
Corneal Ulcer
Corneal Perforation
Eligibility:
All Genders
Brief Summary
Purpose: To evaluate the clinical outcome of patients with refractory Neurotrophic Keratopathy (NK) in stages 2 and 3 treated with topical insulin. Methods: A retrospective, observational analysis of...
Detailed Description
Study type Retrospective, observational, single-center study at the Department of Ophthalmology of Centro Hospitalar Vila Nova de Gaia e Espinho, EPE. Data was obtained from patients' medical record...
Eligibility Criteria
Inclusion
- Inclusion criteria included:
- • Eyes with established diagnosis of NK in stages 2 or 3 refractory to standard treatment\* that underwent topical insulin treatment.
- The diagnosis of NK was based on the following criteria:
- Decreased or absence of corneal sensation; AND
- Corneal injury \[PED and/or corneal ulcer\] refractory to standard treatment\*; AND
- Clinical history of conditions related to trigeminal innervation impairment;
- Standard treatment - lubrication with artificial tears, topical and/or oral antibiotics, topical and/or oral steroids, antiviral drugs, punctal plugs, therapeutic CL, amniotic membrane surgery and temporary tarsorrhaphy.´
- We excluded every patient with corneal ulcer and signs of infection.
Exclusion
Key Trial Info
Start Date :
October 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2020
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04820010
Start Date
October 1 2018
End Date
November 1 2020
Last Update
April 27 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Centro Hospitalar Vila Nova de Gaia e Espinho
Vila Nova de Gaia, Portugal