Status:
ACTIVE_NOT_RECRUITING
Oncogenetic Panel and Integrated Clinical Data Registry Study for Wild Type Gastrointestinal Stromal Tumor Patients
Lead Sponsor:
National Health Research Institutes, Taiwan
Collaborating Sponsors:
National Taiwan University Hospital
Taipei Veterans General Hospital, Taiwan
Conditions:
Gastrointestinal Stromal Tumor (GIST)
Eligibility:
All Genders
20+ years
Brief Summary
The genetic background for cancer treatment may also be different among different areas and races. There is lack of Taiwanese data of genetic alterations in cancer patients. To understand the landscap...
Detailed Description
Cancer is the most common cause of death in Taiwan since 1982. The incidence of cancer is increasing worldwide, including Taiwan. Cancers in early stage can usually treated with surgery with a good pr...
Eligibility Criteria
Inclusion
- Pathologically confirmed GIST.
- The tumors can be resected, unresectable, recurrent or metastatic and the patients had ever received, are receiving or will receive systemic treatment (adjuvant, neoadjuvant or salvage TKI or other targeted agents)
- The tumors were tested for wild type c-KIT and PDGFRA.
- There are archived tumor samples available or the patients agree to do tumor biopsy for oncopanel test if there is no tumor sample or not enough tumor sample available.
- The patients who are systemic treatment naïve or have received prior systemic treatment are all eligible.
- Age - the legal age.
- Life expectancy greater than 6 months
- Capable of understanding and complying with the protocol requirements and signed informed consent.
Exclusion
- Patients will be excluded from the study if they meet any of the following criteria:
- Inability and unwillingness to give informed consent
- Patients do not agree to provide archived tumor samples and blood samples or they do not agree to do tumor biopsy when archived tumor samples are not available.
- Patients refused for collection of clinical data and follow up.
- Mental status is not fit for further treatment or data collection.
Key Trial Info
Start Date :
August 28 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2029
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04821895
Start Date
August 28 2021
End Date
December 31 2029
Last Update
May 7 2025
Active Locations (13)
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1
Changhua Christian Hospital
Changhua, Taiwan
2
Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
3
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan
4
Kaohsiung Veterans General Hospital
Kaohsiung City, Taiwan