Status:

RECRUITING

Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition

Lead Sponsor:

Korea University Anam Hospital

Conditions:

Heart Failure With Preserved Ejection Fraction (HFpEF)

Eligibility:

All Genders

20-80 years

Phase:

NA

Brief Summary

The correlation of coronary microvascular function and body composition with cardiopulmonary exercise capacity will be assessed in patients with heart failure with preserved ejection fraction.

Detailed Description

We will select the patients with chest pain or ischemic symptoms with non-obstructive coronary artery disease (\<50% stenosis) in coronary angiography and preserved ejection fraction (≥50%) in echocar...

Eligibility Criteria

Inclusion

  • Age 20 to 80
  • Typical/atypical chest pain or ischemic symptoms including dyspnea
  • No significant coronary artery stenosis (\>50% stenosis) in coronary angiography or computed tomography
  • Left ventricular ejection fraction ≥50%

Exclusion

  • More than moderate valvular heart disease
  • Congenital heart disease
  • Chronic renal failure (estimated glomerular filtration rate \<30 ml/min/1.73m2) or end-stage renal failure undergoing hemodialysis or peritoneal dialysis
  • Asthma, chronic obstructive pulmonary disease and primary pulmonary hypertension
  • Receiving anticancer drugs
  • Vasculitis associated with autoimmune diseases
  • Patients with difficulty in performing exercise load evaluation (treadmill, bicycle ergometer)
  • Atrial fibrillation
  • Atrioventricular block with more than second degrees, symptomatic bradycardia, cryo-node failure syndrome, Wolff-Parkinson-White (WPW) patients

Key Trial Info

Start Date :

April 15 2021

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

December 31 2025

Estimated Enrollment :

100 Patients enrolled

Trial Details

Trial ID

NCT04822649

Start Date

April 15 2021

End Date

December 31 2025

Last Update

September 2 2025

Active Locations (1)

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Korea University Anam Hospital

Seoul, South Korea