Status:
COMPLETED
Vaccine Response in Patient With Sepsis
Lead Sponsor:
Centre Hospitalier Universitaire de Nice
Conditions:
Sepsis
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Vaccination is established as an effective means of individual and collective protection. Hospitalization is an opportunity not to be missed to catch up on vaccinations in certain fragile patients. Pa...
Eligibility Criteria
Inclusion
- Inclusion Criteria for all patients:
- Age ≥ 18 years old and \<80 years old
- Planned length of hospital stay in infectious disease department ≥ 48 hours
- Indication for vaccination against pneumococcus according to the 2013 HAS recommendations
- Vaccination planned as part of the usual care
- Patient hospitalized for sepsis meeting the sepsis criteria according to the latest consensus of 2016 or SIRS ≥ 2 with documented infection
- Patient having signed the free and informed consent form
- Subject affiliated to social security
- Inclusion Criteria for patients positive to Covid-19:
- PCR SARS-COV 2 \> 0 within 28 days priodi admission and/or,
- scanner compatible with SARS-COV 2 infection.
- Exclusion Criteria:
- Pregnant or breastfeeding women,
- Vulnerable people
- Pneumococcal vaccination according to the prime-boost scheme already carried out less than 5 years old
- Pneumovax vaccination \<1 year
- Known hypersensitivity to the active substances or to any of the excipients or to diphtheria toxoid.
- IgG level\> 1 µg / mL among more than 75% of serotypes at inclusion
- Withdrawal of consent
Exclusion
Key Trial Info
Start Date :
April 19 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 6 2023
Estimated Enrollment :
175 Patients enrolled
Trial Details
Trial ID
NCT04823039
Start Date
April 19 2021
End Date
June 6 2023
Last Update
August 3 2023
Active Locations (1)
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1
University Hospital of Nice
Nice, Provence-Alpes-Côte d'Azur Region, France, 06000