Status:
UNKNOWN
The Effect of Calcium Intake on Calcium and Bone Metabolism During Load Carriage in Women
Lead Sponsor:
Army Health Branch, British Army
Collaborating Sponsors:
University of East Anglia
Osteolabs, GEOMAR
Conditions:
Calcium Deficiency
Eligibility:
FEMALE
18-36 years
Phase:
NA
Brief Summary
This randomised trial will investigate the effect of calcium supplementation on bone and calcium metabolism in women during acute load carriage exercise. This study will test the hypothesis that calci...
Detailed Description
Endurance exercise decreases serum ionised calcium and increases parathyroid hormone and bone resorption. These disturbances to calcium homeostasis can be attenuated by calcium supplementation before ...
Eligibility Criteria
Inclusion
- Female sex;
- Aged 18 to 36 years old;
- Maximal rate of oxygen uptake of ≥ 35 ml∙kg-1∙min-1;
- Weight stable (no change in self-reported body mass ≥ 5% over the previous 3 months);
- BMI between 18 and 30 kg∙m2;
- Not pregnant.
Exclusion
- Evidence of disordered eating (≥ 20 on the EAT-26);
- Self-reported change in body mass of ≥ 5% over the previous 3 months;
- Vitamin D deficient (total 25(OH)D \< 30 nmol∙L-1);
- Maximal rate of oxygen uptake of \< 35 ml∙kg-1∙min-1;
- Total body BMD T-score of \< -1;
- Evidence of menstrual disturbance (oligomenorrhoea: \< 9 menstrual cycles in previous 12 months or amenorrhoea: ≤ 3 menstrual cycles in the previous 12 months);
- Pregnant;
- Current smoker, or stopped smoking within the last three months;
- Taking any medications known to affect bone or calcium metabolism (e.g. treatment for thyroid disorders);
- Self-declared history of heart, liver or kidney disease, diabetes or thyroid disorder;
- Self-reported stress fracture or any other bone injuries in the previous 12 months;
- Anaemia (haemoglobin \<12 g∙/dL-1).
- Currently using the implant, injection, or the progesterone-only pill ('mini pill').
Key Trial Info
Start Date :
March 24 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 19 2023
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04823156
Start Date
March 24 2022
End Date
May 19 2023
Last Update
April 21 2023
Active Locations (1)
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1
Army Health and Performance Laboratory
Camberley, Surry, United Kingdom, GU15 4PQ