Status:
COMPLETED
Activation of Brown Adipose Tissue Metabolism Using Mirabegron
Lead Sponsor:
Université de Sherbrooke
Collaborating Sponsors:
Laval University
Conditions:
Type 2 Diabetes
Eligibility:
MALE
18-35 years
Phase:
NA
Brief Summary
Could sympathomimetics and sympatholytics drugs safe for the management of Type 2 Diabetes (T2D)? Based on recent evidence, we propose that pharmacological stimulation of Beta-3 adrenergic receptor (A...
Detailed Description
In brief, participants will take part in 2 metabolic studies (A and B) performed in random order and at an interval of 7 to 14 days. Each metabolic study will last 8.5 hours with a baseline period of ...
Eligibility Criteria
Inclusion
- Healthy subjects with normal glucose tolerance determined according to an oral glucose tolerance test;
- BMI ≤ 30 kg/m2.
Exclusion
- Plasma triglycerides \> 5.0 mmol/L at fasting;
- More than 2 alcohol consumption per day;
- More than 1 cigarette per day;
- History of total cholesterol level \> 7 mmol/L, of cardiovascular disease, hypertensive crisis;
- Treatment with fibrates, thiazolidinedione, insulin,betablockers or other drugs with effects on insulin resistance or lipid metabolism (exception for antihypertensive drugs, statins or metformin);
- Presence of a noncontrolled thyroid disease, renal or hepatic disease, history of pancreatitis, bleeding diatheses, cardiovascular disease or any other serious medical conditions;
- History of serious gastrointestinal disorders (malabsorption, peptic ulcer, gastroesophageal reflux having required a surgery, etc.); reflux having required a surgery, etc.);
- Presence of a pacemaker;
- Have undergone of PET study or CT scan in the past year;
- Chronic administration of any medication;
Key Trial Info
Start Date :
January 21 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 4 2022
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT04823442
Start Date
January 21 2021
End Date
April 4 2022
Last Update
December 9 2024
Active Locations (1)
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1
Centre de recherche du CHUS
Sherbrooke, Quebec, Canada, J1H 5N4