Status:
RECRUITING
The Effects of Acute Melatonin Supplementation on Cardiovascular Responses to Sympathetic Activation
Lead Sponsor:
University of Oklahoma
Conditions:
Healthy
Eligibility:
All Genders
18-35 years
Phase:
PHASE4
Brief Summary
the purpose of this experiment is to determine if acute melatonin supplementation alters central and peripheral cardiovascular responses to a cold pressor test at rest and during dynamic exercise.
Detailed Description
After IRB approval, experiments will take place in the Human Circulation Research Laboratory in the Department of Health and Exercise on the University of Oklahoma Norman campus. All subjects will com...
Eligibility Criteria
Inclusion
- Healthy men and women
- Women must be premenopausal with a regular menstrual cycle (26-30 days)
Exclusion
- History of autonomic dysfunction
- Cardiovascular diseases
- Diabetes
- Tobacco/nicotine use
- Systolic Pressure \>= 130 mmHg
- Diastolic Pressure \>= 85 mmHg
- Regular melatonin use \>= 1 use/week
- Allergy to melatonin
- Cardiometabolic medication use (e.g. anti-hypertensives, insulin-sensitizing, statins)
- Sex hormone replacement medical use (e.g. testosterone, estrogen, progesterone)
- Pregnancy
Key Trial Info
Start Date :
January 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04831398
Start Date
January 1 2023
End Date
December 1 2026
Last Update
December 6 2024
Active Locations (1)
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1
Department of Health and Exercise Science
Norman, Oklahoma, United States, 73019