Status:
COMPLETED
Mitochondrial Stress, Brain Imaging, and Epigenetics
Lead Sponsor:
Columbia University
Collaborating Sponsors:
Dartmouth College
Centre National de la Recherche Scientifique, France
Conditions:
Mitochondrial Diseases
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The MiSBIE study collects biological, behavioral, psychosocial, neuropsychological, and brain imaging data in participants with either: normal mitochondrial function, individuals with the m.3243A\>G m...
Detailed Description
Age-related physical and cognitive decline, as well as the risk of neurological diseases, are increased by the effects of psychosocial stress. Psychosocial stress triggers neuroendocrine, metabolic, c...
Eligibility Criteria
Inclusion
- Men and women patients between 18 and 55 years of age
- Willing to provide saliva samples and have venous catheter installed for blood collection during the hospital visit
- Willing to provide informed consent and capacity to consent
- Use of effective method of birth control for women of childbearing capacity
- English Speaking
Exclusion
- Individuals with cognitive deficit incapable of providing informed consent will not be included
- Symptoms of flu or other seasonal infection four weeks preceding hospital visit
- Raynaud's syndrome (Raynaud phenomenon)
- Involvement in any therapeutic trials listed on clinicaltrials.gov, including exercise
- Metal inside or outside the body or claustrophobia prohibitive to MRI testing
- Diagnosed with mitochondrial disease m.3243A\>G, or large scale mtDNA deletion (for healthy controls)
Key Trial Info
Start Date :
June 12 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 3 2024
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT04831424
Start Date
June 12 2018
End Date
May 3 2024
Last Update
May 20 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Columbia University Irving Medical Center
New York, New York, United States, 10032