Status:
UNKNOWN
Evaluation of New Diagnostic Indicator of Subclinical Hypercortisolism
Lead Sponsor:
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Conditions:
Adrenal Incidentaloma
Subclinical Hypercortisolism
Eligibility:
All Genders
18-75 years
Brief Summary
The purpose of this study is to evaluate the serum dehydroepiandrosterone sulfate in subclinical hypercortisolism
Detailed Description
In the past few years, with the widespread use of chest and abdominal imaging, the prevalence of adrenal incidentaloma (AIs) has been increasing and now approaches the 8.7% incidence reported in autop...
Eligibility Criteria
Inclusion
- patients with adrenal accidental tumor (diameter \> 1cm) found by physical examination or imaging examination due to non-adrenal diseases
Exclusion
- concomitant use of drugs influencing glucocorticoid metabolism or secretion
- major psychiatric illness or history of excess alcohol intake
- overt clinical features of hypercortisolism
- clinical and endocrine function evaluation (surgery patients at the same time reference to postoperative pathology) revealed primary aldosteronism, pheochromocytoma, adrenocortical carcinoma, adrenal metastasis of cancer, myelolipoma; oncocytoma, congenital adrenal cortex hyperplasia and ganglion cells neuroma/paraganglioma, schwannoma, adrenal hematoma and uncertain diagnosis)
- non-adenoma lesions such as cysts and hemorrhage
- The pregnancy
- Patients with severe underlying diseases (such as liver and kidney failure, acute severe infection, etc.) that may affect the function of the hypothalamus-pituitary-adrenal axis (HPA axis)
Key Trial Info
Start Date :
April 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2023
Estimated Enrollment :
202 Patients enrolled
Trial Details
Trial ID
NCT04833192
Start Date
April 1 2020
End Date
December 30 2023
Last Update
April 15 2022
Active Locations (1)
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1
at Divison of Endocrinology,the Affiliated Drum Tower Hospital of Nanjing University
Nanjing, Jiangsu, China, 210008