Status:
UNKNOWN
Propranolol Versus Propranolol and Clonidine in Sympathetic Hyperactivity After Moderate Traumatic Brain Injury
Lead Sponsor:
Minia University
Conditions:
Traumatic Brain Injury
Eligibility:
All Genders
18-60 years
Phase:
EARLY_PHASE1
Brief Summary
evaluation of the effect of Propranolol versus propranolol and clonidine on decreasing sympathetic hyperactivity after moderate traumatic brain injury
Detailed Description
measuring catecholamine levels after moderate traumatic brain injury after giving propranolol and clonidine
Eligibility Criteria
Inclusion
- GCS on admission between 9 and 12 age 18 up to 60 years both sexes
Exclusion
- history of heart disease, cardiac arrhythmia and myocardial infarction diagnosis ofpreexisting brain dysfunction. impending brain herniation and craniotomy diagnosis of spinal cord injuries. diagnisis of severe liver and renal disease current use of beta blocker and or alpha agonist current using of intravenous vasopressor contraindication to enteral feeding and can not swallow pregnancy
Key Trial Info
Start Date :
January 31 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 22 2021
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT04833218
Start Date
January 31 2020
End Date
July 22 2021
Last Update
April 6 2021
Active Locations (1)
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1
Faculty Of Medicine
Minya, Egypt, 61111