Status:
COMPLETED
Adipose Derived Mesenchymal Stem Cell Characteristics in Anal Fistulas
Lead Sponsor:
University of Aarhus
Collaborating Sponsors:
University of Southern Denmark
UiT The Arctic University of Norway
Conditions:
Perianal Fistula
Adipose Tissue
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This study investigated the cellular and molecular characteristics of AT-MSCs obtained from autologous AT therapy in patients with high transphincteric perianal fistulas of crytoglandular origin. Adip...
Detailed Description
Injection with allogene or autologous stem cells has been reported to be efficient treatment of perianal fistulas. An alternative to this treatment could be injection with freshly collected autologous...
Eligibility Criteria
Inclusion
- high trans-sphincteric fistulas
- fistula confirmed and classified by an MRI.
- seton (\> 6 weeks) prior to fat injection
- informed, written consent.
Exclusion
- Anovaginal fistula
- Active sepsis
- IBD, immunodeficiency, prior pelvic irradiation and malignancy
- Insulin dependent diabetes
- More than 4 prior attempts of fistula closure
- Tobacco smoking or nicotine substitution 8 weeks prior to fat injection.
- Pregnancy
- Psychiatric disorders
- BMI ≥ 35 or BMI\<20
- Active tuberculosis
- Patient less than 18 years
- Unable to undergo MRI
Key Trial Info
Start Date :
January 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2021
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT04834609
Start Date
January 1 2015
End Date
February 1 2021
Last Update
April 8 2021
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