Status:
COMPLETED
Role of Simvastatin Microsponges in Treatment of Periodontitis
Lead Sponsor:
Assiut University
Conditions:
Periodontitis
Eligibility:
All Genders
30-50 years
Phase:
EARLY_PHASE1
Brief Summary
the aim of our study is to enhance the dissolution and subsequently the local penetration of the drug through the sulcus in addition to controlling the drug release so that, the drug could be potentia...
Detailed Description
Patients will be divided randomly into three groups: Group (I);will be treated with subgingival debridement and subgengival injection of chitosan 2% gel containing a microsponges formulated (SV), Grou...
Eligibility Criteria
Inclusion
- patients with chronic periodontitis with minimum two sites of pocket depth \> 5 mm
- patients with normal lipid profile
- nonsmokers
- patients free from any systemic disorders
- committed patients to complete the treatment with follow-ups.
Exclusion
- patients with hyperlipidemia
- patients taking lipid lowering drugs
- smokers
- pregnant
- Lactating women women, patients with mental or psychological illness and medically compromised patients.
Key Trial Info
Start Date :
February 10 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 10 2020
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT04836078
Start Date
February 10 2020
End Date
October 10 2020
Last Update
April 8 2021
Active Locations (1)
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1
Assiut University
Asyut, Egypt, 71111111