Status:
COMPLETED
Rivaroxaban in Type 2 Myocardial Infarctions
Lead Sponsor:
University of Alberta
Conditions:
Type II Myocardial Infarction
Eligibility:
All Genders
45+ years
Phase:
PHASE2
PHASE3
Brief Summary
This trial is the pilot phase of a randomized controlled trial to test the feasibility of recruiting patients with a type 2 myocardial infarction and randomizing them to low-dose rivaroxaban to reduce...
Detailed Description
This trial is an investigator-initiated prospective, single-center, placebo-controlled, double blinded, pilot randomized controlled trial of low-dose rivaroxaban (2.5mg oral twice daily) for 90-days f...
Eligibility Criteria
Inclusion
- Participant age ≥ 65years or \>45 years and an additional risk factor (smoking, diabetes mellitus, hypertension, dyslipidemia or known atherosclerotic disease)
- Rise in troponin level, with one troponin value above the 99th percentile of the upper limit of normal deemed to be due to a type 2 myocardial infarction by the attending team within the past 30 days
- Alive at the time of hospital discharge
Exclusion
- Current use of anticoagulation
- Current use of dual antiplatelet therapy
- Advanced kidney disease (eGFR \<15ml/min)
- Previous hemorrhagic stroke at any time or embolic stroke within the past year
- Previous life-threatening bleeding event
- Life expectancy less than one year
- Anticoagulation recommended conditions - atrial fibrillation, pulmonary embolism, deep vein thrombosis, mechanical heart valves, rheumatic mitral valve disease, left ventricular thrombosis
- Surgery in the previous 30 days
- Inability to provide informed consent in English
- Pregnancy, breastfeeding or child bearing potential
Key Trial Info
Start Date :
April 5 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 3 2023
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT04838808
Start Date
April 5 2021
End Date
January 3 2023
Last Update
March 27 2023
Active Locations (1)
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1
University of Alberta
Edmonton, Alberta, Canada, T6W 1T7