Status:
UNKNOWN
Pathophysiologic Hemodynamics After Primary Unilateral Total Hip Arthroplasty in Patients Receiving ACEIs and ARBs
Lead Sponsor:
Hvidovre University Hospital
Collaborating Sponsors:
Kehlet, Henrik, M.D., Ph.D.
Conditions:
Orthostatic Intolerance
Orthostatic Hypotension
Eligibility:
All Genders
18+ years
Brief Summary
Incidence and pathophysiologic hemodynamics of postoperative orthostatic intolerance and orthostatic hypotension in patients receiving antihypertensives
Detailed Description
Early postoperative mobilization is essential for rapid functional recovery after surgery and it is considered a cornerstone in the so-called fast track multimodal perioperative approach, which includ...
Eligibility Criteria
Inclusion
- Patients undergoing primary unilateral total hip arthroplasty (THA) in spinal anaesthesia in standardized fast-track setting
- Habitual use of angiontensin-Converting Enzyme Inhibitors (ACEIs) and/or angiotensin 2 receptor blockers (ARBs) on any indication
- Patients \> 18
- Patients that understand and speak Danish
- Patients that have provided written informed consent
Exclusion
- Alcohol abuse
- Any type of substance abuse
- Chronic pain treated by habitual use of opioids
- Habitual use of anxiolytic, antidepressant and/or antipsychotic drugs
- History of cerebral apoplexy or transitory cerebral ischemia
- History of previous orthostatic intolerance or hypotension
- History of diabetes mellitus
- History of following diseases of the autonomic nervous system: Parkinson disease, multiple sclerosis, multiple system atrophy, autonomic neuropathies
- Cognitive dysfunction
- Dementia
- American Society of Anesthesiologists (ASA) \> 3
Key Trial Info
Start Date :
December 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2023
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT04842058
Start Date
December 1 2020
End Date
December 1 2023
Last Update
April 12 2021
Active Locations (1)
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1
Hvidovre University Hospital
Copenhagen, Denmark, 2960