Status:
UNKNOWN
CHED - Congenital Hereditary Endothelial Dystrophy: New Paradigm Shift in Therapy Using Topical Eye Drops
Lead Sponsor:
L.V. Prasad Eye Institute
Collaborating Sponsors:
Allergan
Conditions:
Congenital Hereditary Endothelial Dystrophy of Cornea
Eligibility:
All Genders
Up to 6 years
Phase:
PHASE2
Brief Summary
CHED- Congenital Endothelial Endothelial Dystrophy is a condition that causes corneal cloudiness. Since, currently only surgery is being done to cure this condition, we are taking up the research of ...
Detailed Description
Introduction: Corneal endothelial cell loss is often associated with blinding endothelial corneal dystrophies: relatively seen more frequently dominantly inherited (5%) FECD (Fuchs Endothelial Cornea...
Eligibility Criteria
Inclusion
- Children upto 9 years of age diagnosed with CHED (Congenital Hereditary Endothelial Dystrophy) with bilaterally equal corneal involvement
- Patients agreeing on a regular monthly follow-up for a minimum of 6 months
Exclusion
- Patient undergone any other surgery like Penetrating keratoplasty (PK), Descemet stripping automated endothelial keratoplasty (DSEK) and Descemet's membrane endothelial keratoplasty (DMEK), Glaucoma surgeries, in one of both eyes
- Patients with concomitant ophthalmic pathologies like glaucoma, poor corneal surface, dry eye disease, corneal ulcers, systemic inflammatory conditions, cataract, nystagmus, Reduced corneal sensation etc.
- Patients not able to come for follow-ups
- Asymmetrical corneal involvement
- Patients with known allergy to ophthalmic NSAID's
- Patients with asthma or bleeding dyscrasias
- Non-cooperative children
Key Trial Info
Start Date :
December 15 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 15 2022
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04843839
Start Date
December 15 2020
End Date
December 15 2022
Last Update
April 14 2021
Active Locations (1)
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1
L V Prasad Eye Institute
Hyderabad, Banjara Hills, India, 500034