Status:
ACTIVE_NOT_RECRUITING
Remote Ischemic Conditioning With Local Ischemic Postconditioning in High-Risk ST-elevation Myocardial Infarction
Lead Sponsor:
Helios Health Institute GmbH
Collaborating Sponsors:
Heart Center Leipzig - University Hospital
Conditions:
ST Elevation Myocardial Infarction
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The RIP-HIGH trial is a two-arm randomized controlled trial aiming to compare the impact of combined remote ischemic conditioning (RIP) and local ischemic postconditioning (PostC) vs. standard of care...
Detailed Description
Coronary reperfusion by percutaneous coronary intervention is mandatory to salvage ischemic myocardium and to reduce definite infarct size. However, reperfusion itself also causes irreversible myocard...
Eligibility Criteria
Inclusion
- Acute chest pain lasting \<12 h
- ST-elevation at the J-point in two contiguous leads of ≥2 mm in men ≥40 years, ≥2.5 mm in men \<40 years and ≥1.5 mm in women (regardless of age) in V2-V3 and/or ≥1 mm in all other leads (52).
- New or presumed new left bundle branch block or right bundle branch block.
- Killip class ≥II on hospital admission or requirement of diuretics because of clinical congestion.
- Written informed consent.
Exclusion
- Killip class I on hospital admission.
- Prior fibrinolysis.
- Conditions precluding use of RIC (i.e. paresis of the upper limb, presence of an arteriovenous shunt).
- Pregnancy.
- Age \<18 years.
- Severe co-morbidity with a life expectancy \<6 months.
- Participation in another trial.
Key Trial Info
Start Date :
July 5 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2030
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT04844931
Start Date
July 5 2021
End Date
July 1 2030
Last Update
March 13 2025
Active Locations (11)
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1
Medizinische Universität Innsbruck
Innsbruck, Austria, 6020
2
Klinikum Links der Weser
Bremen, Germany
3
Herzzentrum Dresden
Dresden, Germany, 01307
4
Universitätsklinikum Düsseldorf
Düsseldorf, Germany, 40225