Status:
COMPLETED
Mapping of the Human Brainstem During Continence and Micturition: Noninvasive 7-T fMRI Study
Lead Sponsor:
The Methodist Hospital Research Institute
Conditions:
Healthy
Eligibility:
All Genders
18+ years
Brief Summary
The lower urinary tract (bladder, bladder neck, urethra and urethral sphincter) has two functions: Storage (Continence) and voiding (micturition). Lower urinary tract dysfunction (LUTD) includes sympt...
Detailed Description
The current proposal will be the first 7-Tesla study evaluating brain and specifically brainstem control over LUT. The study will utilize a noninvasive functional MRI (fMRI) protocol that allows for e...
Eligibility Criteria
Inclusion
- • Healthy adult male and female volunteers ≥18 years of age with no neurological disease and genitourinary abnormalities will be screened:
- Post-Void Residual (PVR) \< 20% of their bladder capacity OR
- Above 10 percentile of Liverpool nomogram
- AND
- • AUASS score \< 7 will be eligible to participate in the study.
Exclusion
- history of clinically relevant genitourinary malignancy or surgery such as:
- anti-incontinence procedures
- urethral strictures
- advanced pelvic organ prolapse
- any neurological disorders
- history of seizures,
- pregnancy or planning to become pregnant,
- and contraindications to MRI will be excluded.
- Research team members who are involved with the data collection and the data analysis for this study.
Key Trial Info
Start Date :
January 18 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2023
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04846387
Start Date
January 18 2021
End Date
December 31 2023
Last Update
April 10 2025
Active Locations (1)
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1
Houston Methodist Hospital
Houston, Texas, United States, 77030