Status:
UNKNOWN
Rapid Declarative Neocortical Declarative Learning in Aging and Memory Diseases (ANéRAVIMM)
Lead Sponsor:
Rennes University Hospital
Conditions:
Neurological Diseases
Central Nervous System
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Learning a person's name, new words, or simply remembering where the last conversation with a friend was held are examples of associative memory, frequently disturbed in brain pathologies, but also by...
Detailed Description
Three experimental cognitive tasks will be used in the ANéRAVIMM study. The first two tasks have been selected based on the literature and previous work of CHU Rennes team. They are two experiments th...
Eligibility Criteria
Inclusion
- Healthy Volunteers
- aged 18 to 40 years old and aged 60 to 80 years old
- native French speaker
- right-handed
- with a level of education greater than or equal to the Certificate of Primary Education
- free of any medical or psychiatric condition that may interfere with cognition
- Neurological patients
- patients with mild neurocognitive impairment due to Alzheimer's disease
- patients with semantic dementia syndrome
- right-handed patients with a right or left unilateral surgical lesion of the anterior temporal lobe as a result of pharmaco resistant temporal epilepsy, with no seizures in the last 6 months, with a memory quotient greater than 75, and free of internal extra temporal lesions on MRI
- patients with autoimmune limbic encephalitis who have been seizure-free for one month
- 1 KA patient, suffering from the rare syndrome of developmental amnesia
Exclusion
- All participants
- MRI contraindications
- sensory deficit interfering with experimental tests
- protected major (safeguard justice, trusteeship and guardianship) and persons deprived of liberty
- Healthy volunteers
- \- deficit score on the MoCA scale according to current calibrations
- Neurologic patients
- 7-items modified Hachinski ischemic score \>2
- dementia
- epileptic seizure in the month prior to inclusion for epileptic patients undergoing surgery and limbic encephalitis patients
Key Trial Info
Start Date :
April 28 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 28 2024
Estimated Enrollment :
94 Patients enrolled
Trial Details
Trial ID
NCT04846764
Start Date
April 28 2021
End Date
May 28 2024
Last Update
July 28 2023
Active Locations (1)
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1
CHU Rennes
Rennes, France, 35033