Status:
COMPLETED
Role of the Serotonin 5-HT2A Receptor in Mescaline-induced Altered States of Consciousness
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Healthy
Eligibility:
All Genders
25-65 years
Phase:
PHASE1
Brief Summary
Mescaline (the active substance in Peyote and San Pedro cacti) is a classic and long known serotonergic psychedelic substance (hallucinogen) that is widely used for recreational, spiritual, and/or eth...
Eligibility Criteria
Inclusion
- Age between 25 and 65 years old
- Sufficient understanding of the German language
- Understanding of procedures and risks associated with the study
- Willing to adhere to the protocol and signing of the consent form
- Willing to refrain from the consumption of illicit psychoactive substances during the study
- Abstaining from xanthine-based liquids from the evenings prior to the study sessions to the end of the study days
- Willing not to drive a traffic vehicle or operate heavy machinery within 48 hours after substance administration
- Willing to use double-barrier birth control throughout study participation
- Body mass index between 18-29 kg/m2
Exclusion
- Chronic or acute medical condition
- Current or previous major psychiatric disorder
- Psychotic disorder or bipolar disorder in first-degree relatives
- Hypertension (\>140/90 mmHg) or hypotension (SBP10 cigarettes/day)
- Hallucinogenic substance use (not including cannabis) more than 20 times or any time within the previous two months
- Pregnancy or current breastfeeding
- Participation in another clinical trial (currently or within the last 30 days)
- Use of medication that may interfere with the effects of the study medication
- Tobacco smoking (\>10 cigarettes/day)
- Consumption of alcoholic beverages (\>20 drinks/week)
Key Trial Info
Start Date :
August 11 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 27 2023
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT04849013
Start Date
August 11 2021
End Date
March 27 2023
Last Update
March 29 2023
Active Locations (1)
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1
University Hospital Basel, Clinical Trial Unit
Basel, Canton of Basel-City, Switzerland, 4056