Status:
COMPLETED
Effect of Low-dose Esketamine on Postoperative Depression in Patients With Breast Cancer
Lead Sponsor:
Yangzhou University
Conditions:
Depression
Eligibility:
FEMALE
18-65 years
Phase:
NA
Brief Summary
esketamine is an optical isomer of ketamine. Compared with ketamine, esketamine has the characteristics of higher effective value, stronger receptor affinity, less adverse reactions of nervous system,...
Detailed Description
This study intends to explore the effect of small doses of esketamine on patients with breast cancer.WE pay attention to : 1. Safety of low-dose single intravenous injection of esketamine (1)The infl...
Eligibility Criteria
Inclusion
- (1) Female patients who planned to undergo unilateral modified radical mastectomy in breast surgery; (2)Years of education ≥5 years,American Society of Anesthesiologists Ⅰ-II grade; (3) All patients undergoing surgery within 1 week after diagnosis of breast cancer, and do not receive preoperative radiotherapy or chemotherapy; (4) All the patients were married and had children, and were mainly cared for by their immediate family members after surgery.
Exclusion
- (1) Antidepressant treatment was received within the last 2 months; (2) previous personality disorder, intellectual retardation, brain injury or brain disease, combined with schizophrenia, mania and other mental diseases; (3) Preoperative patients with hyperthyroidism or hypothyroidism, severe cardiovascular disease, diabetes, severe blood deficiency, and abnormal heart, lung, liver, and kidney functions; (4) with diseases of the immune system, or use drugs that have obvious effects on the immune system; (5) Pregnancy or lactation;
Key Trial Info
Start Date :
February 10 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 10 2022
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT04850937
Start Date
February 10 2021
End Date
May 10 2022
Last Update
July 28 2022
Active Locations (1)
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1
Affiliated hospital of yangzhou university
Yangzhou, Jiangsu, China, 225100