Status:
COMPLETED
Identification of miRNAs Associated With Gender Difference in Osteoarthritis Patients
Lead Sponsor:
Istituto Ortopedico Rizzoli
Conditions:
Osteoarthritis
Eligibility:
All Genders
50-75 years
Brief Summary
The biological study involves the collection of samples from male and female patients (intraoperative waste tissue, blood and synovial fluid), suffering from mild and moderate-severe OA, who undergo e...
Detailed Description
Osteoarthritis (OA) is a chronic degenerative joint disease of considerable socio-economic impact, of which a primary and a secondary form are distinguished. Primary OA is a mild form that occurs main...
Eligibility Criteria
Inclusion
- Patients of both sexes suffering from OA in hospital for the surgical treatment of OA (endo- or arthroplasty, or arthroscopy) with an interval of at least three months from any previous infiltrative treatment of any kind;
- Patients with a Kellgren and Lawrence (KL) \[Kohn 2016\] score greater than or equal to grade III will be enrolled in the 'Moderate-severe OA' group and those with grade I and II KL scores in the 'MIld OA' group;
- Patients able to provide the list of medications and supplements taken;
- Patients able to provide informed consent to treatment.
Exclusion
- Patients who have undergone previous joint surgery or who have excessive joint deformity.
- Patients with recent trauma, osteonecrosis or OA induced by previous or current joint infection;
- Patients with metabolic pathologies;
- Patients with previous or current oncological pathologies;
- Women in a climacteric (date of last menstruation less than one year);
- Patients with severe cognitive deficits or psychiatric disorders;
- Autoimmune diseases (eg rheumatoid arthritis).
Key Trial Info
Start Date :
March 21 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 31 2024
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT04851210
Start Date
March 21 2022
End Date
July 31 2024
Last Update
September 23 2024
Active Locations (1)
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1
Dipartimento Rizzoli Sicilia - Istituto Ortopedico Rizzoli
Bagheria, Palermo, Italy, 90011