Status:
RECRUITING
Protocol-based Management and Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy
Lead Sponsor:
Peking University First Hospital
Conditions:
Antithrombotic Therapy
Perioperative Care
Eligibility:
All Genders
Phase:
NA
Brief Summary
The purpose of this pragmatic interventional study is to evaluate whether a protocol-based management of antithrombotic drugs can reduce a composite of perioperative outcomes in patients with chronic ...
Detailed Description
Aging population and chronic medical disease make the management of surgical patients more complex. About one tenth of patients scheduled for surgery are taking antithrombotic medications. Coagulation...
Eligibility Criteria
Inclusion
- 1\. Patients with continuing antithrombotic therapy (including antiplatelet and/or anticoagulant therapies) for cardiovascular and cerebrovascular diseases for more than 2 weeks.
- 2\. Patients who have one or more of the following situations: (1) non-valvular atrial fibrillation with a CHA2DS2-VASc score \>4; (2) post-artificial valve replacement (including mitral valve, ball-cage valve or tilting disc aortic valve); (3) venous thromboembolism occurred within 1 year, or venous thromboembolism with other high-risk factors which require long-term anticoagulation treatment; (4) coronary heart disease with coronary stent implantation, thrombolytic therapy or other coronary procedures within 2 years, or who had undergone coronary artery bypass grafting within 1 year, or who experienced myocardial infarction or acute coronary syndrome within 1 year; (5) a history of stroke/transient ischemic accident within 1 year, or a history of cervical or intracranial revascularization treatment within 1 year; (6) peripheral arterial disease.
- 3\. Patients who are scheduled to undergo intra-abdominal surgery (including general and urologic surgery).
- 4\. Patients who sign written informed consents.
Exclusion
- 1\. Refuse to participate.
- 2\. Emergency surgery.
- 3\. Unable to complete the preoperative assessment and follow-up plan.
- 4\. Other reasons that are considered unsuitable for study participation by the investigators or the attending doctors.
Key Trial Info
Start Date :
April 21 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
526 Patients enrolled
Trial Details
Trial ID
NCT04852406
Start Date
April 21 2021
End Date
January 1 2026
Last Update
July 31 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034