Status:
UNKNOWN
The Temporal Cellular Landscape of the Adaptive Immune System in Patients With Acute Stroke
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Conditions:
Stroke, Acute
Eligibility:
All Genders
18+ years
Brief Summary
Despite novel acute therapies the global burden of stroke remains high worldwide. Targeting the immune response after stroke has the potential to improve recovery in all stroke patients. Experimental ...
Detailed Description
Rationale: despite novel acute therapies the global burden of stroke remains high worldwide. Targeting the immune response after stroke has the potential to improve recovery in all stroke patients. Ex...
Eligibility Criteria
Inclusion
- Inclusioncriteria
- In order to be eligible to participate in part 1 of this study (serial blood sampling), a subject must meet all of the following criteria:
- age 18 years or older,
- clinical symptoms of hemispheric ischemic stroke due to occlusion of a large vessel
- an onset of symptoms less than 48 h
- a score of 1 or more on the National Institutes of Health Stroke Scale (NIHSS)
- admission to hospital
- written informed consent obtained
- For the control arm of part 1 of the study:
- age 18 years or older
- increased risk of cardiovascular disease (defined as a previous cardiovascular event other than stroke or one of the following risk factors: smoking, hypertension, hypercholesterolemia or diabetes mellitus)
- written informed consent obtained
- scheduled blood draw ordered at the Neurology outpatient clinic at Amsterdam UMC (location AMC) for non-vascular non-immunological disease
Exclusion
Key Trial Info
Start Date :
April 15 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 15 2023
Estimated Enrollment :
103 Patients enrolled
Trial Details
Trial ID
NCT04852445
Start Date
April 15 2021
End Date
August 15 2023
Last Update
April 21 2021
Active Locations (1)
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1
Academic University Medical Center Amsterdam
Amsterdam, North Holland, Netherlands, 1100 AZ