Status:
RECRUITING
NEUROIMAGING OF ADOLESCENT BORDERLINE PERSONALITY DISORDER WITH AND WITHOUT POST-TRAUMATIC STRESS DISORDER
Lead Sponsor:
University Hospital, Caen
Collaborating Sponsors:
CHU de Rouen - Accueil
Centre Hospitalier Universitaire de Caen
Conditions:
Borderline Personality Disorder
Eligibility:
FEMALE
13-18 years
Phase:
NA
Brief Summary
Borderline personality disorder (BPD) is a common mental disorder in adolescents with significant individual and societal repercussions, characterized over the long term by emotional hyperresponsivene...
Detailed Description
A - RESEARCH OBJECTIVES 1. Primary objective: • Compare the hippocampal volume between adolescent girls with BPD with and without PTSD 2. Secondary objectives: * 1 - Evaluate the link, transv...
Eligibility Criteria
Inclusion
- For the 3 groups:
- female
- Age between 13 and 17 years inclusive
- Oral and written comprehension of the French language
- Affiliation to the social security scheme
- Informed consent signed by the legal representatives holding the exercise of parental authority and the adolescent herself
- For patients:
- Diagnosis of borderline personality disorder according to the criteria of the Diagnostic and Statistical Manual for mental disorders, fifth edition (DSM-5; American Psychiatric Association, 2013; SIDP-IV)
- Level of general psychopathology compatible with participation in the study (score\> 20 on the CGA-S)
- TB + / PTSD + group:
- \- Post-traumatic stress disorder according to DSM-5 criteria (American Psychiatric Association, 2013; K-SADS-PL)
- In the control group :
- Absence of mental disorder according to DSM-5 criteria (American Psychiatric Association, 2013; K-SADS-PL and SIDP-IV)
- Oral and written comprehension of the French language
- Informed consent signed by the legal representative, the holder (s) of the exercise of parental authority and the adolescent herself
Exclusion
- \- Illiteracy / illiteracy
- Sensory disorder (visual, auditory)
- Severe chronic psychiatric comorbidity: autism spectrum disorder, intellectual disability, schizophrenia spectrum disorder and other psychotic disorders, bipolar disorder
- Severe or current brain pathology (chronic neurological disease, encephalitis, history of severe head trauma), alertness disorder
- History of anoxic coma
- Contraindication to MRI (magnetic foreign body, claustrophobia, contraindication to prolonged lying down)
- Severe physical pathology in progress
- Moving outside the Normandy region planned within 18 months
- The inclusion of the subject in another biomedical research protocol (during the present study)
- Intellectual deficit (IQ \<70)
- Pregnant or breastfeeding women
Key Trial Info
Start Date :
March 11 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2028
Estimated Enrollment :
99 Patients enrolled
Trial Details
Trial ID
NCT04852744
Start Date
March 11 2022
End Date
June 1 2028
Last Update
July 25 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Caen University Hospital
Caen, France