Status:
UNKNOWN
Comprehensive Assessment of Interconnection Between Brain Emotional Activity and Coronary Plaque Instability
Lead Sponsor:
Korea University Guro Hospital
Conditions:
Atherosclerosis, Coronary
Emotional Stress
Eligibility:
All Genders
20-75 years
Brief Summary
Emotional stress is associated with future cardiovascular events. However, the biological interconnection between brain emotional neural activity and acute plaque instability is not fully understood. ...
Detailed Description
Thirty two patients with multivessel coronary artery disease (including both stable angina and acute coronary syndrome), who have at least one severe obstructive lesion (\>70% diameter stenosis) that ...
Eligibility Criteria
Inclusion
- Age: greater than 20, less than 75
- Patients with severe coronary atherosclerosis (diameter stenosis \>70%) requiring coronary revascularization
- Reference vessel diameter: between 2.5 and 4.0 mm
- Obtained informed consent from voluntary participants before study enrollment
Exclusion
- Complex coronary lesion (ostial lesion, unprotected left main lesion, chronic total occlusion, grafted vessels, etc)
- Reference vessel diameter: less than 2.5 mm, greater than 4.0 mm
- Coronary lesion with heavy calcification
- Hemodynamic instability during coronary intervention
- Contraindication to antithrombotic therapy
- Chronic renal insufficiency (Serum creatinine \>2.0mg/dL)
- Severe liver dysfunction (aspartate transaminase or alanine transferase \> 5 times of upper normal limit)
- Pregnancy or potential pregnancy
- Life expectancy less than 1 year
- Patient refused to sign the informed consent at enrollment
Key Trial Info
Start Date :
February 14 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04853511
Start Date
February 14 2022
End Date
December 31 2024
Last Update
August 24 2022
Active Locations (1)
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1
Korea University Guro Hospital
Seoul, South Korea, 08308