Status:
RECRUITING
Ph I/II Study of E7777 Prior to CAR-T for R/R LBCL
Lead Sponsor:
Masonic Cancer Center, University of Minnesota
Conditions:
DLBCL
Diffuse Large B Cell Lymphoma
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
This is a multicenter Phase I study to determine the maximum tolerated dose (MTD) of E7777 when given prior to cyclophosphamide/fludarabine (CY/Flu) lymphodepletion (LD) chemotherapy and an FDAapprove...
Detailed Description
E7777 is a recombinant fusion toxin consisting of full-length human IL-2 fused to the catalytic domains of diphtheria toxin. This trial is designed to augment lymphodepletion prior to CAR-T cells by a...
Eligibility Criteria
Inclusion
- Diagnosis of a relapse or refractory (r/r) B cell lymphoma, for which treatment with tisagenleucel (Kymriah), Axicabtagene (Yescarta) or Lisocabtagene Maraleucel (Breyanzi) is planned, including :
- diffuse large B-cell lymphoma (DLBCL) not otherwise specified,
- high grade B-cell lymphoma
- DLBCL arising from follicular lymphoma
- Primary mediastinal B cell lymphoma
- Follicular lymphoma grade 3B
- And considered at high risk for progression after CAR-T therapy by meeting one or more of the following factors:
- refractory to last line of therapy/remission of less than 12 months
- myc over expression \>40% in any prior biopsy or bcl2/bcl6 and c-myc re-arrangement (double/triple hit)
- 2 sites of extranodal disease
- IPI ≥ 3
- Elevated LDH at the time of relapse
- Has secured coverage for Kymriah, Yescarta,Breyanzi administration
- Age 18 years or older at the time of signing the consent
- ECOG Performance status of 0, 1, or 2
- Adequate bone marrow reserve (may be transfusion dependent)
- Adequate organ function at enrollment and within 14 days of planned E7777 treatment as defined in Section 4.1.7
- Hemodynamically stable and LVEF ≥ 50% confirmed by echocardiogram or MUGA
- Grade 1 dyspnea (CTCAE v5) and SpO2 \> 91% on room air
- Sexually active females of child-bearing potential and males with partners of child bearing potential must agree to use effective contraception during therapy
- Provides voluntary written consent prior to the performance of any research related activities.
Exclusion
- Pregnant or breastfeeding - Females of childbearing potential must have a blood test or urine study within 14 days prior to study enrollment to rule out pregnancy. All females will be considered to be of childbearing potential unless they are postmenopausal (amenorrheic for at least 12 consecutive months, in the appropriate age group, and without other known or suspected cause) or have been sterilized surgically (i.e., bilateral tubal ligation, total hysterectomy, or bilateral oophorectomy, all with surgery at least 1 month before dosing)
- Known bone marrow involvement, if history of bone marrow involvement must have a BM biopsy to rule-out current involvement
- Prior allogeneic transplant
- Ocular disease or complaints visual acuity impairment, color or shape distortion, or blurred vision - potential participants are required to have an ophthalmological examine as part of screening
- Active CNS involvement by malignancy (history of CNS disease with negative CSF by flow cytometry and/or stable findings on brain MRI are acceptable)
- Uncontrolled active hepatitis B or hepatitis C
- Active or inactive HIV infection
- Untreated active bacterial, viral or fungal infection (e.g. blood culture positive ≤ 72 hours prior to enrollment)
- History of heart failure or pulmonary edema, evidence of pleural effusion or active lower extremity edema
- Uncontrolled unstable angina and/or myocardial infarction within 3 months of enrollment
- Investigational medicinal product within the last 7 days prior to apheresis or CAR-T infusion
Key Trial Info
Start Date :
June 9 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04855253
Start Date
June 9 2021
End Date
December 1 2025
Last Update
July 2 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Minnesota, Masonic Cancer Center
Minneapolis, Minnesota, United States, 55455