Status:
COMPLETED
Targeting Individual Alpha Frequencies to Enhance Perceptual Timing
Lead Sponsor:
University of Minnesota
Conditions:
Psychosis
Schizophrenia
Eligibility:
All Genders
18-64 years
Brief Summary
This is a single-blind randomized within-subject crossover design study that will be conducted in 2 phases. In Phase 1, up to 50 participants, after signing informed consent and determining eligibilit...
Detailed Description
The proposed pilot study will assess the feasibility of transcranial alternating current stimulation (tACS) to enhance aspects of attention in people with psychotic disorders. If a participant agrees...
Eligibility Criteria
Inclusion
- Psychosis Participants:
- Meet diagnostic criteria for a psychotic disorder (schizophrenia, schizoaffective disorder, schizophreniform disorder, major depressive disorder with psychotic features, bipolar disorder with psychotic features, psychosis disorder not otherwise specified, or unspecified schizophrenia spectrum disorder), as defined by the MINI (Mini-International Neuropsychiatric Interview)
- Are age 18-64 (inclusive)
- Fluent in written and spoken English
- Have an outpatient status of at least 1 month prior to participation
- Has been on a stable dose of psychiatric medication for at least one month prior to participation (titration to a lower dose of psychotropic medications under supervision of a psychiatrist can be allowed at the discretion of the investigators)
Exclusion
- History of seizures or epilepsy
- Metallic cranial plates, screws, or implanted devices
- History of craniotomy
- History of stroke
- History of eczema on scalp
- Pre-existing sores or lesions at sites of tACS electrode placement
- Non-removable facial piercings
- Current or possibility of current pregnancy
- Active suicidal ideation at screening or baseline assessments, or previous intent to act on suicidal ideation with a specific plan, preparatory acts, or an actual suicide attempt within the last 3 months, as indicated by the MINI and/or C-SSRS (All participants will complete the suicide module of the MINI. If participants express any suicidal ideation on the MINI, staff will complete the C-SSRS \[Columbia-Suicide Severity Rating Scale\].)
- WTAR (Wechsler Test of Adult Reading) standardized score below 70
- Any reason our tCS (transcranial stimulation) or EEG caps cannot be placed on their head
- Control Participants:
- Inclusion Criteria:
- Are age 18-64 (inclusive)
- Fluent in written and spoken English
Key Trial Info
Start Date :
November 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 9 2023
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT04856657
Start Date
November 1 2021
End Date
February 9 2023
Last Update
February 14 2023
Active Locations (1)
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1
University of Minnesota
Minneapolis, Minnesota, United States, 55455