Status:
COMPLETED
Application of Machine Learning Method in Validation of Screening Cognitive Test for Parkinsonisms
Lead Sponsor:
Ospedale Generale Di Zona Moriggia-Pelascini
Collaborating Sponsors:
Ospedale di Vipiteno-Sterzing (SABES-ASDAA)
Conditions:
Primary Parkinsonism
Secondary Vascular Parkinson Disease
Eligibility:
All Genders
Brief Summary
Based on a prospectively collected data analysis, a new tool, namely CoMDA (Cognition in Movement Disorders Assessment) is developed by merging each item of Mini-Mental State Examination (MMSE), Montr...
Detailed Description
A prospectively data-base was setting up, collecting CoMDA and in-depht-neuropsychologocal-battery scores, obtained from the evaluation of 500 patients with parkinsonisms. Data were analyzed to compar...
Eligibility Criteria
Inclusion
- diagnosis of idiopathic PD according to the MDS clinical diagnostic criteria (Postuma et al. 2015); b) diagnosis of PSP according to the MDS clinical diagnostic criteria (Höglinger et al. 2017); c) diagnosis of MSA according to the second diagnostic consensus statement (Gilman et al. 2008); d) diagnosis of VP according to Zijlmans et al (Zijlmans et al. 2004).
Exclusion
- a) any focal brain lesion detected with brain imaging studies (CT or MRI); b) diagnosis of clinically relevant psychiatric disorders, psychosis (evaluated with Neuropsychiatric Inventory) and/or delirium; c) diagnosis of dementia or MCI; d) diagnosis of neurological diseases other than PD or atypical parkinsonian syndromes; e) other medical conditions negatively affecting the cognitive status; f) disturbing resting and/or action tremor, corresponding to scores 2-4 in the specific items of MDS Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III, such as to affect the psychometric evaluation; g) disturbing dyskinesia, corresponding to scores 2-4 in the specific items of MDS-UPDRS III, such as to affect the psychometric evaluation; h) auditory and/or visual dysfunctions impairing the patient´s ability to perform cognitive tests.
Key Trial Info
Start Date :
January 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 31 2020
Estimated Enrollment :
562 Patients enrolled
Trial Details
Trial ID
NCT04858893
Start Date
January 1 2017
End Date
August 31 2020
Last Update
May 12 2021
Active Locations (1)
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1
"Moriggia Pelascini" Hospital
Gravedona E Uniti, Como, Italy, 22015