Status:
COMPLETED
Developing Dual-channel Transcranial Alternating Current Stimulations Targeting Negative Symptoms in Schizophrenia
Lead Sponsor:
Shanghai Mental Health Center
Conditions:
Schizophrenia
Transcranial Alternating Current Stimulations
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Negative symptoms are core symptoms in schizophrenia which play an important role in clinical outcomes and impede patients to return to society. Anti-psychotic medicines have shown limited effect in i...
Eligibility Criteria
Inclusion
- meet the DSM-V diagnostic criteria for schizophrenia;
- present with prominent negative symptoms with PANSS-negative scores \>20, at least one score of PANSS N1-N7 \>3, and reductive ratio of PANSS-negative in the past two weeks before recruitment \<10%;
- stable usage and dosage of anti-psychotic medicines in the past two weeks and during the tACS intervention.
- age within 18-60;
- illness duration \>1year;
- education at least 6 years;
- written consent of receiving tACS intervention.
Exclusion
- Meet any DSM-V diagnostic criteria of any other psychiatric disorders besides schizophrenia ;
- any history of alcohol or substance dependence in the past 3 months;
- any other major physical disease (i.e., Sensorimotor disorder, neurological disease);
- any metal implants or any other tACS contraindication.
Key Trial Info
Start Date :
April 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04859504
Start Date
April 1 2021
End Date
July 31 2024
Last Update
December 12 2024
Active Locations (2)
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1
Zhengjiang Mental Health Center
Zhenjiang, Jiangsu, China
2
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China, 200030