Status:
UNKNOWN
Hydroxychloroquine for Treatment of Non-Severe COVID-19
Lead Sponsor:
Makerere University
Conditions:
Covid19
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Currently there are no proven treatments for COVID-19 and current standard therapy is supportive care with oxygen supplementation and treatment of symptoms. Several re-purposed and new drugs have been...
Detailed Description
Currently there are no proven treatments for COVID-19 and current standard therapy is supportive care with oxygen supplementation and treatment of symptoms. Several re-purposed and new drugs have been...
Eligibility Criteria
Inclusion
- Patients with a confirmed positive Polymerase chain reaction(PCR) test for SARS COV-2
- Adults of ≥ 18 years
- Evidence of a personally signed and dated informed consent document indicating that the participant(or their legal representative) has been informed of all pertinent aspects of the study
Exclusion
- Patients with contraindication to the use of hydroxychloroquine e.g. known allergy to hydroxychloroquine
- Patients enrolled in another interventional study which may interfere with study results
- Patients on medication that are known to have clinically significant interactions with the study drug e.g. digoxin, piperaquine, lumefantrine.
- Patients presenting with severe/critically ill COVID-19 (World Health Organization Ordinal scale for clinical improvement score of 5 or more)
- Patients with a fever( temperature ≥ 37.5 degrees centigrade) and a positive rapid diagnostic test (RDT) result for malaria
- Patients with corrected QT interval (QTc) prolongation of \> 450ms for males and \>470ms for females
- Pregnant or breastfeeding women
- Patients on chronic hydroxychloroquine use
Key Trial Info
Start Date :
September 18 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2021
Estimated Enrollment :
105 Patients enrolled
Trial Details
Trial ID
NCT04860284
Start Date
September 18 2020
End Date
December 1 2021
Last Update
April 26 2021
Active Locations (1)
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1
Namboole COVID-19 treatment unit
Kampala, Uganda