Status:
RECRUITING
The Effect of HIIT, MICT in Patients With Myocardial Infarction
Lead Sponsor:
Guangdong Provincial People's Hospital
Collaborating Sponsors:
Zhongshan Hospital Of Traditional Chinese Medicine
Conditions:
Myocardial Infarction
Cardiopulmonary Disease
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
This study will investigate the effect of a 12-weeks cardiac rehabilitation training (HIIT, MICT) program on VO2peak and cardiac fibrosis in patients, and evaluate the effects of HIIT on endothelial f...
Detailed Description
Eligible and consenting patients are randomized (block randomization) in a 1:1:1 ratio. According to the number of 180 samples calculated by the sample size, the random number table containing 1-180 (...
Eligibility Criteria
Inclusion
- Aged 18 -75 years
- Acute myocardial infarction (AMI) patients between 6 weeks and 3 months and had been underwent revascularization, and New York Heart Association functional classification (NYHA) Class I-III; (AMI confirmed by the World Health Organization definition (presence of symptoms of ischemia and changes in electrocardiogram) or the Third Universal Definition of Myocardial Infarction (elevation of a cardiac biomarker along with presence of either symptoms of myocardial infarction or changes in electrocardiogram))
- Willing and able to attend the complete cardiac rehabilitation(CR)program on their own，assigned the Informed consent form.
- Complete the cardiopulmonary exercise testing (CPET) at enrollment or has the CPET report within 1 month.
Exclusion
- High-intensity exercise frequently
- Currently participating in any other clinical trials
- Have any other diseases which limit their life to less than a year (e.g. severe valvular disease, recurrent ventricular arrhythmias, NYHA Class IV heart failure, severe aortic incompetence, severe atrial fibrillation, cancers, and end-stage renal or liver disease)
- Dementia ; disability or sports contraindication
- Severe acute liver failure
- Severe acute renal failure
- Unstable vital signs
- Site investigators consider that the patient will be unable to complete the study and/or attend for follow-up.
Key Trial Info
Start Date :
May 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 31 2025
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT04863677
Start Date
May 1 2021
End Date
October 31 2025
Last Update
September 29 2025
Active Locations (1)
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1
Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital
Guangzhou, Guangdong, China, 510000