Status:
COMPLETED
How Secreted-embryo-derived Trypsin Initiates, Maintains and Terminates Ca2+ Signals in Uterine Epithelial Cells
Lead Sponsor:
ART Fertility Clinics LLC
Collaborating Sponsors:
University Women's Hospital Tübingen
Conditions:
Infertility
Infertility, Female
Eligibility:
FEMALE
18-36 years
Brief Summary
To develop a deeper understanding of endometrial-embryo crosstalk through basic research, uncover therapeutic targets and to improve reproductive outcome.
Detailed Description
Pregnancy is a complex and highly coordinated physiological process that involves implantation of a hatched blastocyst into a decidualizing endometrium. The main purpose of implantation is to ensure t...
Eligibility Criteria
Inclusion
- Couples with primary / secondary infertility who are planned to undergo ICSI treatment with PGT-A
- Age of each partner above 18 years
Exclusion
- Couples with consanguinity (couple who is 1st or 2nd degree cousins)
- Couples in whom the female partner has a history of:
- Chemotherapy or radiation which impacts the ovarian reserve
- Surgery at the ovaries / adnex region
- Endometriosis
- Couples in whom the male partner has a history of:
- Chemotherapy / Radiation which impacts the semen result
- Surgery at the testicles
- Vasectomy
- Surgery for reversal of vasectomy
- Semen obtained by fine needle aspiration (FNA) or Testicular sperm extraction (TESE)
Key Trial Info
Start Date :
November 4 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 15 2023
Estimated Enrollment :
81 Patients enrolled
Trial Details
Trial ID
NCT04865367
Start Date
November 4 2021
End Date
May 15 2023
Last Update
July 17 2024
Active Locations (1)
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1
ART Fertility Clinics LLC
Abu Dhabi, United Arab Emirates, 60202