Status:
COMPLETED
Citrate Versus Heparin in Continuous Renal Replacement Therapy :
Lead Sponsor:
Bangkok Metropolitan Administration Medical College and Vajira Hospital
Collaborating Sponsors:
King Chulalongkorn Memorial Hospital
Chiang Mai University
Conditions:
Acute Kidney Injury
Citrate
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
This study is a prospective, multicenter, open-label randomized trial comparing regional citrate anticoagulation (RCA) with heparin-free protocol. The function mode was continuous venovenous hemodiafi...
Detailed Description
Twenty patients were randomized into heparin group and 11 patients were in citrate group. The cardiac performance were not significantly different between 2 groups at every time point. The inflammator...
Eligibility Criteria
Inclusion
- need for CRRT,
- no contraindication to CRRT
Exclusion
- patients with previous history of chronic kidney disease (CKD) (baseline serum creatinine \> 2 mg/dL (male) or \> 1.5 mg/dL (female)
- history of renal transplantation
- known pregnancy
- previous dialysis within 30 days
- severe liver disease
- end stage heart disease or untreatable malignancy
- moribund patients with expected survival less than 30 days
- previous use of heparin or other anticoagulant, antiplatelet within 7 day except use for deep vein thrombosis
- active bleeding at the time of enrollment and/or severe coagulopathy
- receiving blood or blood components prior to enrollment
- hemoglobin less than 7.5 g/dL and/or platelet count less than 100,000/mm3
- previous underlying clotting disorders such as hypercoagulable state
- severe malnutrition (Body mass index (BMI ) less than 18)
- underwent CRRT for other reasons besides acute kidney injury (AKI)
Key Trial Info
Start Date :
February 4 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2021
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT04865510
Start Date
February 4 2019
End Date
March 31 2021
Last Update
April 29 2021
Active Locations (1)
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1
Faculty of Medicine ,Vajira hospital,Navamindradhiraj University
Bangkok, Thailand, 10300