Status:
RECRUITING
Uterine Natural Killer (uNK) Cell Expression in Patients With Repeated ICSI Failures: A Multicenter Cohort Study
Lead Sponsor:
Tanta University
Collaborating Sponsors:
Mansoura University
Benha University
Conditions:
Repeated Implantation Failure
ICSI Failure
Eligibility:
FEMALE
20-40 years
Brief Summary
uterine NK (uNK) cells are characterized by a high expression of CD56 (CD56brihgt), lack of CD16 expression, high secretion of cytokines and rather low cytotoxic activity. It has been shown that uNK c...
Detailed Description
For occurrence of the "window of implantation", the endometrium must proliferate, increase in thickness, then, after ovulation, adequately respond to progesterone, and become receptive. Ultrasound exa...
Eligibility Criteria
Inclusion
- Patients with IVF/ICSI failures more than 2 times
- Age 20-40 years
Exclusion
- prior uterine surgery
- immunological disease
- previous testing to uNK cells
Key Trial Info
Start Date :
May 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04867759
Start Date
May 1 2021
End Date
December 1 2024
Last Update
February 28 2024
Active Locations (1)
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1
Adel Elgergawy
Tanta, Egypt, 3111