Status:
COMPLETED
Intubating Conditions During Rapid Sequence Induction in Elderly With Either Suxamethonium 1.0 mg/kg or Rocuronium 1.0 mg/kg
Lead Sponsor:
Matias Vested
Conditions:
Intubation Conditions
Eligibility:
All Genders
80+ years
Phase:
PHASE4
Brief Summary
The aim of this study is to determine the proportion of excellent tracheal intubation conditions at 60 seconds after administration of either rocuronium 1.0 mg/kg or suxamethonium 1 mg/kg in patients ...
Detailed Description
Elderly patients are frail and susceptible to complications in the perioperative period. They are at higher risk of major morbidity and mortality and are characterized by a reduction in cardiac output...
Eligibility Criteria
Inclusion
- Age ≥ 80
- Scheduled for surgery under general anesthesia with indication for rapid sequence induction
- American Society of Anesthesiologists physical status classification (ASA) I to IV
- Informed consent (see appendix 1)
- Body mass index (BMI) \< 35 kg/m2
- Read and understand Danish
Exclusion
- Neuromuscular disease
- Known allergy to rocuronium and/or suxamethonium
- Known hyperkalemia \> 5 mM
- Previous malignant hyperthermia
- Known homozygote plasmacholinesterase gene mutation variant a or s
- Known impaired kidney function defined as estimated glomerular filtration rate (eGFR) \< 30
Key Trial Info
Start Date :
August 12 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 17 2024
Estimated Enrollment :
102 Patients enrolled
Trial Details
Trial ID
NCT04868409
Start Date
August 12 2021
End Date
March 17 2024
Last Update
March 19 2024
Active Locations (4)
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1
Rigshospitalet
Copenhagen, Denmark, 2830
2
Bispebjerg Hospital
Copenhagen, Denmark
3
Department of Anaesthesiology, Pain and Respiratory Support, Rigshospitalet Glostrup
Glostrup Municipality, Denmark
4
Holbæk Hospital
Holbæk, Denmark