Status:
COMPLETED
Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction
Lead Sponsor:
Brigham and Women's Hospital
Conditions:
Glucose Intolerance
Sleep Deprivation
Eligibility:
All Genders
20-40 years
Phase:
NA
Brief Summary
This project is designed to test for the first time whether glucose metabolism is differentially impaired by sleep restriction with and without additional exposure to artificial light at night (ALAN).
Detailed Description
Laboratory studies have shown that sleep restriction to 4-6h per night for durations varying from one to 14 days reduces glucose tolerance in otherwise healthy adults, but the mechanisms by which insu...
Eligibility Criteria
Inclusion
- Healthy adults with conventional and regular sleep-wake timing
- Non-smokers
- Completion of medical, psychological, and sleep screening tests
- Able to spend 33 consecutive days/nights in the laboratory
- Normal color vision
Exclusion
- History of neurological or psychiatric disorder
- History of sleep disorder or regular use of sleep-promoting medication
- Current prescription, herbal, or over-the-counter medication use
- Traveling across 2 or more time zones within past 3 months
- Donating blood within past 8 weeks
- Worked night or rotating shift work within past 3 years
- Hearing impairment, visual impairment
- History of eye trauma or surgery
- Drug or alcohol dependency
Key Trial Info
Start Date :
March 15 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 30 2024
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT04868539
Start Date
March 15 2022
End Date
May 30 2024
Last Update
October 14 2025
Active Locations (1)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115