Status:
ACTIVE_NOT_RECRUITING
Post-Marketing Study of Prucalopride Safety In Pregnancy
Lead Sponsor:
Takeda
Collaborating Sponsors:
The Organization of Teratology Information Specialists
Conditions:
Chronic Idiopathic Constipation (CIC)
Eligibility:
FEMALE
Brief Summary
This study collects information on pregnant women with ongoing constipation who took prucalopride and those who did not take prucalopride. The main aim of the study is to learn if any medical problems...
Eligibility Criteria
Inclusion
- Cohort 1: Prucalopride-Exposed (MOTEGRITY, RESOTRAN) Cohort:
- Pregnant women.
- Exposure to MOTEGRITY or RESOTRAN (generic forms of prucalopride not allowed) for the treatment of chronic idiopathic constipation (CIC) or irritable bowel syndrome-constipation (IBS-C), for any number of days, at any dose, and at any time from the 1st day of the LMP up to and including the 12th week after the first day of the LMP. If the date of LMP is unclear, or if a first-trimester ultrasound has been done and the estimated date of conception is more than one week discrepant from the menstrual period calculation, the first-trimester ultrasound-derived date will be used to calculate a date for LMP and conception.
- Agree to the conditions and requirements of the study including the interview schedule, and release of medical records.
- Cohort 2: Disease-Matched Comparison Cohort:
- Pregnant women.
- Diagnosed with CIC or IBS-C; frequency matched to the exposed group by disease indication, with the indication validated by medical records when possible.
- Agree to the conditions and requirements of the study including the interview schedule, and release of medical records.
Exclusion
- Cohort 1: Prucalopride-Exposed (MOTEGRITY, RESOTRAN) Cohort
- Women who have first contact with the project after prenatal diagnosis of any major structural defect.
- Women who have enrolled in the prucalopride cohort study with a previous pregnancy (women may only enroll once in the Prucalopride Pregnancy Cohort Study).
- Women who have used prucalopride for an indication other than CIC or IBS-C.
- Women who do not have exposure in the first trimester of pregnancy.
- Retrospective enrollment after the outcome of pregnancy is known (i.e. the pregnancy has ended prior to enrollment).
- Results of a diagnostic test are positive for a major structural defect prior to enrollment. However, women who have had any normal or abnormal prenatal screening or diagnostic test prior to enrollment are eligible as long as the test result does not indicate a major structural defect.
- Cohort 2: Disease-Matched Comparison Cohort:
- Women who have first contact with the project after prenatal diagnosis of any major structural defect.
- Exposure to prucalopride (brand name or generic) anytime during the current pregnancy; may or may not have taken another medication for their disease in the current pregnancy.
- Women who have enrolled in the prucalopride cohort study with a previous pregnancy (women may only enroll once in the Prucalopride Pregnancy Cohort Study).
- Retrospective enrollment after the outcome of pregnancy is known (i.e. the pregnancy has ended prior to enrollment).
- Results of a diagnostic test are positive for a major structural defect prior to enrollment. However, women who have had any normal or abnormal prenatal screening or diagnostic test prior to enrollment are eligible as long as the test result does not indicate a major structural defect.
Key Trial Info
Start Date :
May 21 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2027
Estimated Enrollment :
127 Patients enrolled
Trial Details
Trial ID
NCT04869280
Start Date
May 21 2021
End Date
February 1 2027
Last Update
August 13 2025
Active Locations (1)
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1
University of California San Diego
La Jolla, California, United States, 92093