Status:
UNKNOWN
The Dynamic Change of MMN in Patients With Sepsis Associated Encephalopathy
Lead Sponsor:
Chinese Medical Association
Conditions:
Sepsis-Associated Encephalopathy
Mismatch Negativity
Eligibility:
All Genders
18-80 years
Brief Summary
Sepsis-associated encephalopathy (SAE), is one of the most common organ dysfunction during the acute phase in sepsis and septic shock. Electroencephalogram (EEG) and auditory evoked potentials (AEPs),...
Detailed Description
Patient characteristics (including age and sex), date and time of ICU admission, category of admission (medical, surgical or emergency), main reasons for admission, co-morbidities, complications and d...
Eligibility Criteria
Inclusion
- ages between 18 and 80 years;
- expected stay in the ICU of \> 72 h;
- patients diagnosed with sepsis or septic shock;
- informed consent was signed by the patient or relatives;
Exclusion
- at terminal stage of disease;
- primary brain injury (such as traumatic brain injury, stroke, cardiac arrest, intracranial infection, epilepsy, Alzheimer's disease, Parkinson disease and meningitis etc.);
- acute mental deterioration secondary to non-septic metabolic disorders with organ dysfunction (hepatic encephalopathy, pulmonary encephalopathy, severe electrolyte imbalance, severe blood glucose disorders etc.);
- history of craniocerebral surgery;
- psychiatric illness;
- use of psychiatric medications;
- impaired hearing; participated in other clinical trial;
- pregnant or lactating women;
- expected death within 72 h after admission.
Key Trial Info
Start Date :
February 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2022
Estimated Enrollment :
84 Patients enrolled
Trial Details
Trial ID
NCT04870983
Start Date
February 1 2021
End Date
February 1 2022
Last Update
May 4 2021
Active Locations (1)
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1
Nanjing Drum Tower Hospital
Nanjing, Jiangsu, China, 210008