Status:
RECRUITING
Examining tDCS Effect on Cannabis Use Disorder in Patients With Schizophrenia
Lead Sponsor:
Centre Hospitalier Universitaire de Saint Etienne
Collaborating Sponsors:
Direction Générale de l'Offre de Soins
Conditions:
Schizophrenia
Cannabis-Induced Disorder
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Cannabis use disorder is a frequent comorbidity of schizophrenia, associated with increased symptoms and less adherence to therapy. Validated care has limited effectiveness in this population and deve...
Detailed Description
Stimulation will be performed using a Neurocan DC-Stimulator Plus with two 7×5 cm sponge electrodes soaked in a saline solution. Electrodes will be placed in accordance with the international 10-20 el...
Eligibility Criteria
Inclusion
- Schizophrenia diagnostic according to DSM (Diagnostic and Statistical Manual of mental disorder) 5 criteria, without change in psychotropic treatment since at least 4 weeks
- Moderate to severe cannabis use disorder according to DSM 5 criteria and active consumption during the last 7 days
- Subjects motivated to reduce or quit their cannabis consumption
- Patients with ambulatory compulsory care may be included
Exclusion
- Other substance use disorder, excluding nicotine, according to DSM 5 criteria
- Other current psychiatric disorder according to DSM 5 criteria, excluding personality disorder
- Inpatient hospitalization
- History of head injury, neurological disorder with cerebral consequence or severe unstable somatic disorder
- Pregnancy or no contraception
- Contraindications for tDCS and/or MRI (implanted material, uncontrolled epilepsy, intracranial hypertension)
Key Trial Info
Start Date :
February 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT04871048
Start Date
February 15 2023
End Date
March 1 2026
Last Update
March 18 2025
Active Locations (8)
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1
CH Le Vinatier Service universitaire d'addictologie de Lyon
Bron, France, 69678
2
Centre Hospitalier Universitaire Service d'Addictologie et Pathologies Duelles
Clermont-Ferrand, France, 63000
3
CHU de Clermont-Ferrand Service de Psychiatrie
Clermont-Ferrand, France, 63000
4
Service Hospitalo-Universitaire d'Addictologie CHU de Dijon
Dijon, France, 21079