Status:
UNKNOWN
TBS Over DLPFC in Elderly Refractory Depression
Lead Sponsor:
Kaohsiung Veterans General Hospital.
Conditions:
Major Depression
Eligibility:
All Genders
60-85 years
Phase:
NA
Brief Summary
The study aim to examine the effect of Thea-burst stimulation over bilateral dorsolateral prefrontal cortex (DLPFC) among patients with LLD on mood condition and relevant biomarkers.
Detailed Description
Thea-burst stimulation (TBS) is a novel form of rTMS, providing greater modulation effect on neural activity. So far, no study was conducted to use TBS as treatment in LLD. Therefore, we aim to examin...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Aged 60 to 85 years
- Major depression disorder
- Under a stable dose of all psychotropic medication during the stimulation period.
- Exclusion Criteria
- Having any current psychiatric comorbidity or history of substance dependence.
- Having active suicidal ideation currently.
- Having severe physical illness, recent and/or current unstable medical disorders.
- Having history of cancer or chemotherapy.
- Dementia or MMSE\<24.
- Having TMS contraindicated (seizure disorder, history of seizures, metal in the head, pacemakers, history of craniotomy)
Exclusion
Key Trial Info
Start Date :
July 6 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04872465
Start Date
July 6 2022
End Date
July 31 2024
Last Update
January 17 2023
Active Locations (1)
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1
Department of Psychiatry, Kaohsiung Veterans General Hospital
Kaohsiung City, Taiwan, 813