Status:
COMPLETED
Vascular Dysfunction During Physical Inactivity
Lead Sponsor:
University of Utah
Conditions:
Aging
Vascular Endothelium
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Prolonged periods of reduced activity are associated with decreased vascular function and muscle atrophy. Physical inactivity due to a sedentary lifestyle or acute hospitalization is also associated w...
Eligibility Criteria
Inclusion
- Individuals who have recently undergone surgery or injury requiring inactivity
Exclusion
- Cardiac abnormalities considered exclusionary by the study physician (congestive heart failure, coronary artery disease, right-to-left shunt)
- Uncontrolled endocrine or metabolic disease
- Glomerular filtration rate \< 45 mL/min/1.73 m\^2 or evidence of kidney disease or failure
- Vascular disease or risk factors of peripheral atherosclerosis
- Risk of deep vein thrombosis including family history of thrombophilia, pulmonary emboli, deep vein thrombosis
- Use of anticoagulant therapy
- Elevated systolic pressure \> 180 or a diastolic blood pressure \> 110
- Implanted electronic devices such as pacemakers, infusion pumps, stimulators
- Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma
- Currently on a weight-loss diet or body mass index \> 35 kg/m\^2
- Inability to abstain from smoking for duration of study
- History of \> 20 pack per year smoking
- Positive for human immunodeficiency virus, hepatitis B or hepatitis C
- Recent anabolic or corticosteroids use (within 3 months)
- Subjects with hemoglobin or hematocrit lower than accepted lab values
- Agitation/aggression disorder
- History of stroke with motor disability
- Recent history (\< 12 months) of gastrointestinal bleed
- Depression diagnosis
- Alcohol or drug abuse
- Liver disease (AST/ALT 2 times above the normal limit, hyperbilirubinemia)
- Respiratory disease (acute upper respiratory infection, history of chronic lung disease with resting oxygen saturation \< 97% on room air)
- Pregnancy
Key Trial Info
Start Date :
March 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2021
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT04872998
Start Date
March 15 2019
End Date
March 31 2021
Last Update
February 16 2024
Active Locations (1)
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1
VA Medical Center Building
Salt Lake City, Utah, United States, 84148