Status:
COMPLETED
Metoclopramide vs Placebo for Prevention of Pneumonia in Acute Stroke
Lead Sponsor:
Shaheed Zulfiqar Ali Bhutto Medical University
Conditions:
Acute Stroke
Aspiration Pneumonia
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Pneumonia is a major cause of mortality and morbidity in patients with acute stroke fed via nasogastric tubes and may be because of vomiting and gastro-esophageal regurgitation. The aim of the study w...
Detailed Description
Patients admitted with no signs of pneumonia within 7 days of stroke onset and 48 hours of insertion of a nasogastric tube will be recruited into a single-blind randomized placebo-controlled study who...
Eligibility Criteria
Inclusion
- Patients of either gender.
- Patients within 7 days of acute ischemic or hemorrhagic stroke confirmed by computed tomographic scan of the brain who required nasogastric feeds for \>24 hours, and could be recruited within 48 hours of NGT insertion
- Age above 13 years.
Exclusion
- Patients with aspiration pneumonia at the time of presentation.
- Patients with a history of chronic neurodegenerative diseases that could affect swallowing (e.g. Parkinson disease and motor neuron disease)
- Poor postural control (unable to sit up for swallowing assessment).
- Esophageal disorders,
- Contraindications to metoclopramide.
Key Trial Info
Start Date :
May 2 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 2 2021
Estimated Enrollment :
106 Patients enrolled
Trial Details
Trial ID
NCT04873297
Start Date
May 2 2021
End Date
October 2 2021
Last Update
October 19 2021
Active Locations (1)
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1
Shaheed Zulfiqar Ali Bhutto Medical University
Islamabad, Pakistan, 44000